In 1995, she and business partner Nancy Juvonen formed the production company Flower Films, with its first production the 1999 Barrymore film Never Been Kissed. Flower Films has gone on to produce the Barrymore vehicle films Charlie's Angels, 50 First Dates, and Music and Lyrics, as well as the cult film Donnie Darko. Barrymore's more recent projects include He's Just Not That into You, Beverly Hills Chihuahua, Everybody's Fine and Going the Distance. A recipient of a star on the Hollywood Walk of Fame, Barrymore appeared on the cover of the 2007 People magazine's 100 Most Beautiful issue.
She is the niece of Diana Barrymore and the grandniece of Lionel Barrymore, Ethel Barrymore and Helene Costello the great-great-granddaughter of John Drew and actress Louisa Lane Drew, and the great grandniece of Broadway idol John Drew, Jr. and silent film actor/writer/director Sidney Drew. She is also the god-daughter of director Steven Spielberg,and Sophia Loren.Her first name, Drew, was the maiden name of her paternal great-grandmother, Georgie Drew Barrymore; her middle name, Blyth, was the original surname of the dynasty founded by her great-grandfather, Maurice Barrymore
Barrymore's career began when she was auditioned for a dog food commercial at 11 months old. When she was bitten by her canine co-star, the producers were afraid she would cry, but she merely laughed, and was hired for the job. She made her film debut in Altered States (1980), in which she got a small part. A year later, she landed the role of Gertie, the younger sister of Elliott, in E.T. the Extra-Terrestrial, which made her famous. She received a Golden Globe nomination for Best Supporting Actress in 1984 for her role in Irreconcilable Differences, in which she starred as a young girl divorcing her parents. In a review in the Chicago Sun-Times, Roger Ebert states: "Barrymore is the right actress for this role precisely because she approaches it with such grave calm."
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