After beginning her career in theatre, Anderson achieved international recognition for her role as Special Agent Dana Scully on the American television series The X-Files. During the show's nine seasons, Anderson won an Emmy, Golden Globe, and Screen Actors Guild awards. Her film work includes The House of Mirth (2000), The Mighty Celt (2005), The Last King of Scotland (2006), and two X-Files films, The X-Files (1998) and The X-Files: I Want to Believe (2008). She was nominated for BAFTA, Emmy and Golden Globe awards for her role as Lady Dedlock in the BBC television adaptation Bleak House (2005).
Anderson moved to Los Angeles in 1992, spending a year auditioning. Although she had once vowed she would never do TV, being out of work for a year changed her mind. Anderson did Home Fires Burning for a cable station, as well as the audio book version of Exit to Eden. She broke into mainstream television in 1993, with a guest appearance on the collegiate drama, Class of '96, on the fledgling Fox Network.As a result of her guest appearance in Class of 96, Anderson was sent the script for The X Files at the age of 24. She decided to audition because "for the first time in a long time, the script involved a strong, independent, intelligent woman as a lead character." Producer Chris Carter wanted to employ her, but Fox wanted someone with previous TV exposure and greater sex appeal. Fox sent in more actresses, but Carter stood by Anderson, and she was eventually cast as Special Agent Dana Scully. Anderson got the part assuming it would run for 13 episodes, the standard minimum order for American TV networks. Filmed in Vancouver and then in Los Angeles, the series would run for nine seasons, and included two films, released in 1998 and 2008. During her time on The X Files, Anderson won several awards for her portrayal of Special Agent Scully, including an Emmy Award, Golden Globe and two Screen Actors Guild awards for "Best Actress in a Drama Series." While filming, Anderson met assistant art director Clyde Klotz, whom she would eventually marry.
In 2006, Anderson was nominated for a British Academy Television Award (BAFTA) for Best Actress and won the Broadcasting Press Guild Television and Radio Award for Best Actress for her role in Bleak House. Anderson also received an Emmy nomination for "Outstanding Lead Actress in a Miniseries or Movie" for her performance as Lady Dedlock. She was nominated for a Golden Satellite Award and Golden Globe for her performance in Bleak House and came in second place in the Best Actress category of the 2005 BBC Drama website poll for her performance as Lady Dedlock (Billie Piper came in first and Anna Maxwell Martin came in third).During 2006 and 2007, Anderson appeared in two British films: The Last King of Scotland (2006) and Straightheads (2007).
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